Choroidal osteoma american academy of ophthalmology. This tumor can be complicated by choroidal neovascularization which is a cause of impaired vision in this condition. Aug 08, 2019 osteoid osteoma is a benign osteoblastic tumor that was first described in 1930 by bergstrand. Routine fundus photography 18 months before presentation demonstrated a normal retina and choroid without evidence of the lesion. Although the ophthalmoscopic and topographic appearance of sclerochoroidal calcification is characteristic, it is often unrecognized or misdiagnosed. In ocular oncology, oct provides axial resolution to approximately 7 microns with crosssectional images.
Enhanced depth imaging optical coherence tomography of. On examination of the retina, it appears as an orangeyellow lesion usually located near the optic disc, often bilaterally. Diagnosis can be made by imaging studies such as ct scanning, and permanent effective treatment can be achieved through percutaneous surgical techniques. Epidemiology choroidal osteomas are typically found in young caucasian women 1. Typically, affected patients are young and otherwise healthy women 2. Choroidal osteoma definition of choroidal osteoma by. The authors introduce a 42yearold woman with a choroidal osteoma. This rare, benign choroidal tumour is being recognized with increasing frequency, and is important to remember in the differential diagnosis of any unusual mass in the ocular fundus lest it be mistaken for a more sinister lesion. Acknowledgment the authors would like to thank dr vandana dwivedi for her ideas, editing, and completing this paper. Choroidal osteoma co is a rare benign tumor of the choroid, which is composed of mature bone trabecular andor compact and vascular channels 1,2,3,4. In our case, the clinical feature of the tumor was atypical for all differential diagnoses, including choroidal osteoma and amelanotic malignant melanoma, so it was extremely challenging to make a clinical diagnosis as choroidal osteoma using conventional noninvasive examinations. Choroidal osteoma, a benign tumor of mature bone, first appeared in a textbook in 1963 but was misdiagnosed as a calcified choroidal hemangioma reese 1963. Choroidal osteoma usually occurs in 2030 year old, healthy, white women as a welldefined, unilateral 75%, solitary, yellow orange, slowgrowing juxtapapillary lesion. Its recurrence is rare 8,18, with only one case described in the literature 19.
Choroidal osteoma choroidal osteoma fluorescein angiography demonstrates subretinal neovascularization at the macular margin. Combine pdfs in the order you want with the easiest pdf merger available. Although various theories such as trauma and infection have been proposed, it is difficult to establish the pathogenesis of osteoma. Choroidal osteomas are rare benign ossifying tumors that appear as irregular slightly elevated, yellowwhite, juxtapapillary, choroidal mass with welldefined geographic borders, depigmentation of the overlying pigment epithelium. Department of ophthalmology, north texas retina consultants, usa. A healthy 20yearold female presented to the oculoplastics clinic with a 9month history of left upper lid droopiness. If you are looking for a way to combine two or more pdfs into a single file, try pdfchef for free. Choroidal osteoma co is a rare, ossifying benign tumor originated in the choroid that typically occurs in otherwise healthy young women 1,2. Osteoid osteoma is a benign tumor of the skeletal system which primarily targets younger individuals, and most commonly develops in long bones. Although choroidal osteoma is benign, it usually results in poor vision over time. A second case was presented in 1975 in the verhoeff society by van dyk and published in 1978 by williams, font, van dyk, and riekhof williams et al. Choroidal osteoma, first described by van dyk in 1975, is a rare benign ocular tumor characterized by cancellous bone. Solitary osteoma cutis is by far the most common form, and typically occurs as a reactive process in association with other inflammatory or neoplastic conditions. Choroidal osteoma with neovascular membrane managed with.
On occasion, a choroidal osteoma may be associated with subretinal neovascularization abnormal blood vessels beneath the retina, which are typically treated with laser. Systemically, there were no other findings of familial adenomatous polyposis gardner syndrome. Multiple choroidal osteomas in a boy a rare presentation. Choroidal osteoma often occurs as a unilateral condition in young females and supposedly associated with congenital causes, inflammatory conditions, and endocrine disorders. Crawford cm, igboeli oc 2017 unilateral choroidal osteoma with evidence of choroidal neovascularization based on ocular coherence. To investigate the effect of aflibercept in a rare case of choroidal neovascularization cnv secondary to choroidal osteoma co and refractory to ranibizumab and bevacizumab. Choroidal osteoma article about choroidal osteoma by the. Merge pdf, split pdf, compress pdf, office to pdf, pdf to jpg and more. Choroidal osteoma is a rare, benign, ossifying tumour of the choroid of unknown aetiology. Choroidal osteoma was first reported by gass et al.
Choroidal osteoma is a rare tumor which features intraocular bone formation. This simple webbased tool lets you merge pdf files in batches. Ciliary body melanoma ciliary body melanoma behind the iris as seen through a dilated pupil. Diagnosis of choroidal osteoma was established using spectral domain optical coherence tomography oct, fundus fluorescein angiography ffa, indocyanine green angiography icg, and b. Split pdf files into individual pages, delete or rotate pages, easily merge pdf files together or edit and modify pdf files. It is characterized by proliferation of either compact or cancellous bone in an endosteal or periosteal location. Multimodal imaging in choroidal osteoma international. The authors present enhanced depth imaging optical coherence tomography edi oct and fundus autofluorescence faf characteristics of a patient with bilateral choroidal osteoma and try to make a correlation between two imaging techniques.
The diagnostic imaging appearances of three choroidal osteomas osseous choristomas are presented. New tests that were unavailable during the first diagnosis were performed such as fundus autofluorescence or enhanced depth imagingoptical coherence tomography edioct. Co is typically unilateral 80% of cases and it usually affects young healthy female. Osteomas most frequently occur in the frontal and ethmoid sinuses, and are rare in the maxillary sinus. Pdf merge combinejoin pdf files online for free soda pdf. Our pdf merger allows you to quickly combine multiple pdf files into one single pdf document, in just a few clicks. We present a case of choroidal osteoma with choroidal neovascularization as a complication. Choroidal osteoma is a choristomatous lesion postulated to be congenital in nature. Patients usually present with symptoms of blurred vision, metamorphopsia, photophobia or visual field defects. In the posterior pole, a flat choroidal lesion, with very high reflectivity and shadowing of the posterior orbital contents, was observed in both eyes. A rare, benign tumor of the eye, composed of calcified bone.
Color photograph of a choroidal osteoma with associated choroidal neovascularization. Visual acuity of the right eye was decreased to 20200 from macular rpe loss and choroidal neovascularization scarring. They may be complicated by choroidal neovascularization cnv which may lead to loss of vision, and in such cases photocoagulation therapy may be of benefit, although overall response is poor 3. Optical coherence tomography oct has revolutionized the field of ophthalmology since its introduction 20 years ago. Osteoma cutis may manifest as a solitary firm papule, multiple papules, or even plaques. Described herein is the case of a 16year old female presenting with a peripapillary lesion diagnosed as choroidal osteoma on multimodal imaging. Co is typically unilateral 80% of cases and it usually affects young healthy female patients. In the hand, osteoid osteoma is more commonly located in the phalanges and carpal bones. Osteomas may be detected with routine radiographic examination or the tumors may enlarge and cause symptoms. There are no reports of osteoma malignant transformation 1,6,17.
Discussion choroidal osteomas are benign juxtapapillary choroidal ossified tumors. A 45yearold male with corelated cnv in his left eye received prior two intravitreal 1. It is characterized by a yellowish, well demarcated lesion in the juxtapapillary or macular area. A longterm followup of choroidal osteoma intraocular. It has thin, delicate trabeculae that enclose large medullary spaces like those in cancellous bone. The osteoma cutis may persist long after the inflammatory condition has resolved.
Choroidal osteoma is a benign calcified tumor that can focally replace normal vascular tissue with mature bone. Below we show how to combine multiple pdf files into a single document. Backgroundaims to assess spectral domainoptical coherence tomography sdoct contribution to choroidal osteoma characterisation. In the largest case series on choroidal osteoma including 74 eyes of 61 patients followed up for a period of 26years, carol and colleagues demonstrated that choroidal osteoma is a disease of young females 2. Osteoma is a benign tumor composed of compact mature bone arising on the surface of the bone. The term choroidal osteoma was coined by gass in 1978 9. Though present from birth, it is usually diagnosed during the second or third. Choroidal osteoma co is a benign and rare tumor that is composed of mature bone cells and is more prevalent in females1. In the largest case series on choroidal osteoma including 74 eyes of 61 patients followed up for a period of 26 years, carol and colleagues demonstrated that choroidal osteoma is a disease of young females. Osteoma is a benign often asymptomatic neoplasm, consisting of welldifferentiated matured bone. Examinations indicate that pcv could be more like a neovasculopathy occurring in a variety of different diagnoses other than a distinct abnormality of the inner choroidal vasculature 2. Jaffe described it in 1935 and was the first to recognize it as a unique entity. Dec 27, 20 osteoid osteoma bone scan a bone scan is helpful in detecting the doubledensity sign, which is a focal area of increased activity with a second smaller area of increased uptake superimposed on it, is said to be diagnostic of osteoid osteoma.
Ultrasonography shows both hemangioma and osteoma as dense lesions, but osteoma is hyperreflective and casts a shadow. Choroidal osteomas are rare benign calcific masses of the globe. Diagnosis and monitoring of choroidal osteoma through. Choroidal osteoma is a benign tumor of the choroid composed of mature bone. Retinal astrocytic hamartoma versus choroidal osteoma. The radiographic features consist of a central oval or round nidus surrounded first by a radiolucent area followed by another area of sclerotic bone. In bilateral cases, the tumors can appear relatively symmetric or can be asymmetric, in different stages of development, growth, or decalcification. Calcifications in the eye may be present in the choroid and retinal pigment epithelium rpe and may be secondary to trauma, chronic inflammation and infection, hypercalcemia or hyperparathyroidism. Rescue therapy with intravitreal aflibercept for choroidal.
Spectral domainoptical coherence tomography analysis of. Choroidal osteoma rare benign tumour of the choroid, typically occurring unilaterally in the juxtapapillary or macular areas. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. The diagnosis is mainly clinical and relies on the appearance of the lesion on the examination of the posterior pole. Between 8 and 30 percent of cases remain asymptomatic. The proximal femur is the most common site of occurrence.
After 45 years of followup, choroidal osteoma showed slight enlargement in each eye and choroidal neovascularization and retinal pigment epithelium rpe changes had developed in the right eye. An amelanotic choroidal nevus can be relatively flat like a choroidal osteoma but a nevus differs in that it has less distinct margins and can have drusen on. Soda pdf merge tool allows you to combine two or more documents into a single pdf file for free. Irregular shape, slightly elevated and typically display a fine superficial vascular network. A 16yearold caucasian female with a 6month history of decreased visual acuity and metamorphopsia in the left eye is reported. This free online tool allows to combine multiple pdf or image files into a single pdf document. Appearances of choroidal osteomas with diagnostic imaging.
Osteoid osteoma19 yr old male withpain in in the dorsalaspect of the medial aspect of left mid foot. Osteoid osteoma mri mri has not been useful in the diagnosis of osteoid osteoma. Clinical presentation involves intense localized pain, which is often not relieved by analgesics. Our patient exhibited the characteristic findings of choroidal osteoma.
Solitary idiopathic choroiditis sic retina associates. Co is often located in the juxtapapillary or macular region and is unilateral in the majority of cases2. Choroidal osteoma co is a rare benign ossifying tumor with mature bone replacing choroid and presenting as a yelloworange lesion on fundus examination. Retina today enlargement of choroidal osteoma in a child. It is generally unilateral, seen in young females, mostly in the juxtapapillary and macular region appearing as irregular slightly elevated, deep orangeyellow choroidal mass with welldefined scalloped borders. Some publications report a benefit with intravitreal bevacizumab 9. Osteoma treatment is based on complete surgical removal, on the base, where the bone cortical is located. Open access full text article choroidal osteoma with. Choroidal excavation in choroidal osteoma complicated by. Department of ophthalmology, shimane medical university, izumo.
Over time, colour changes from yellow orange to yellowwhite. Aug 27, 2008 osteoid osteoma is a benign tumor of the growing skeleton. When developing in the medullary cavity, it is known as enostosis. The role of ct in the evaluation of choroidal osteoma and the distinctiveness of the ct findings are stressed. Choroidal osteoma is a rare osseous benign tumour typically occurring in otherwise healthy young women. The most common complication of co is choroidal neovascularization cnv, an important cause of. Osteoid osteoma of the femoral head treated by radiofrequency. Choroidal osteoma choroidal osteoma with scalloped edges, pigment on surface and yellow coloration.
Unilateral choroidal osteoma with evidence of choroidal. Choroidal osteoma choroidal osseous choristoma is a benign tumor of unknown etiology first described by gass et al 1978. Intravitreal ranibizumab in a patient with choroidal. The lesion is most commonly located in the cortex of long bones where it is associated with dense, fusiform, reactive sclerosis. Originally intended primarily for retina specialists to image the macula, it has found its role in other subspecialties that include glaucoma, cornea, and ocular oncology. Oct 22, 2011 paranasal sinus osteomas are rare benign tumors. Amelanotic choroidal melanoma differs from choroidal osteoma in that it has a yellowbrown color, more elevation and a less welldefined margin. Osteoma in a child choroidal osteoma is a rare intraocular bony tumor that typically manifests as a yellowwhite, welldemarcated mass with geographic pseudopodal margins. It is typically found in healthy young females in the second or third decades of life fig. Surgical intervention is generally indicated for patients whose pain is unresponsive to medical therapy, those who cannot tolerate prolonged use of nonsteroidal antiinflammatory drugs nsaids, and those who are not amenable to activity restrictions.
Choroidal osteoma is a rare benign ossifying disorder of the choroid. Osteoid osteoma is a benign skeletal neoplasm composed of osteoid and woven bone that rarely exceeds 1. Objective to provide longterm followup information on a large series of patients with choroidal osteoma. Osteoid osteoma is a relatively common benign bone tumor. It may be classified as peripheral, central, or extraskeletal.
Choroidal osteoma is an ossified tumor first described in 1978 by gass and associates. Figure 2 from choroidal osteoma osseous choristoma. She reports that she recently failed a school screening. Choroidal osteoma is a benign ossifying tumor characterized by mature bone replacing choroid. Mar 24, 2011 we present a case report highlighting the unusual location and atypical imaging characteristics of an osteoid osteoma in the juxtaarticular region of the femoral head, and treatment of the condition with radiofrequency ablation. While ophthalmoscopy and fluorescein angiography reveal suggestive ophthalmic findings, echography, plain radiography, and especially computed tomography ct are important in establishing the correct diagnosis. Enhanced depth imaging optical coherence tomography revealed a. An osteoma is a benign osteogenic tumor characterized by compact or cancellous bone proliferation. Choroidal osteoma related vision loss is not usually treatable. Two eyes of a patient with choroidal osteoma underwent complete ophthalmic examination. Choroidal osteoma with neovascular membrane managed with aflibercept and yellow laser raphael pereira da silva, leonardo dias alencar, carlos augusto moreria junior and carlos moreiraneto department of retina and vitreous, eye hospital of parana, brazil submission.
Deze gratis online tool maakt het mogelijk om meerdere pdf bestanden of afbeeldingen te combineren in een pdf document. An osteoid osteoma is a benign noncancerous bone tumor that usually develops in the long bones of the body such as the thighbone and shinbone. It presents with pain, which is usually worse at night. Choroidal osteomas are benign, juxtapapillary, choroidal tumors that mandate no treatment. A peripheral osteoma arises from the periosteum, a central osteoma from the endosteum, and an extraskeletal osteoma in the soft tissue 14. The diagnosis of choroidal osteoma is mainly clinical. The diagnosis is clinical and can be confirmed with the use of fluorescein or indocyanine angiography, optical coherence tomography, computed tomography.
Optical coherence tomography of retinal and choroidal tumors. Aug 08, 2019 initial treatment of osteoid osteoma is nonoperative. Pdf enhanced depth imaging optical coherence tomography. They occur predominantly in young median age, 20 years females 90%. Osteoid osteomas can affect people of all ages but they occur more frequently in children and young adults. This treatment option is low in both risk and morbidity and is therefore the best option in lesions that are difficult to access surgically because of the risks. Case report with clinical and angiographic correlation. Acquired choroidal osteoma latin american journal of.589 1318 380 845 1335 643 1140 758 855 854 877 796 1206 895 270 1060 1241 512 867 1159 32 87 1174 1091 1397 225 1328 312 1577 659 238 983 456 362 567 883